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Chin. Opt. Lett.
 Home  List of Issues    Issue 08 , Vol. 16 , 2018    10.3788/COL201816.081701


3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging
Zhongwen Cheng1;2, Haigang Ma2, Zhiyang Wang2, and Sihua Yang1;2
1 MOE Key Laboratory of Laser Life Science &
Institute of Laser Life Science, [South China Normal University], Guangzhou 51 0631 , China
2 College of Biophotonics, [South China Normal University], Guangzhou 510631, China

Chin. Opt. Lett., 2018, 16(08): pp.081701

DOI:10.3788/COL201816.081701
Topic:Medical optics and biotechnology
Keywords(OCIS Code): 170.5120  170.0110  170.3880  170.3010  

Abstract
Photoacoustic (PA) microscopy comes with high potential for human skin imaging, since it allows noninvasively high-resolution imaging of the natural hemoglobin at depths of several millimeters. Here, we developed a PA microscopy to achieve high-resolution, high-contrast, and large field of view imaging of skin. A three-dimensional (3D) depth-coding technology was used to encode the depth information in PA images, which is very intuitive for identifying the depth of blood vessels in a two-dimensional image, and the vascular structure can be analyzed at different depths. Imaging results demonstrate that the 3D depth-coded PA microscopy should be translated from the bench to the bedside.

Copyright: © 2003-2012 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Received:2018/5/16
Accepted:2018/6/6
Posted online:2018/7/17

Get Citation: Zhongwen Cheng, Haigang Ma, Zhiyang Wang, and Sihua Yang, "3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging," Chin. Opt. Lett. 16(08), 081701(2018)

Note: This work was supported by the National Natural Science Foundation of China (Nos. 11774101, 61627827, 81630046, and 91539127), the Science and Technology Planning Project of Guangdong Province, China (No. 2015B020233016), the Distinguished Young Teacher Project in Higher Education of Guangdong, China (No. YQ2015049), and the Science and Technology Youth Talent for Special Program of Guangdong, China (No. 2015TQ01X882).



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