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Chin. Opt. Lett.
 Home  List of Issues    Issue 03 , Vol. 16 , 2018    10.3788/COL201816.031702

Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment
Mingjun Xu, Peng Lei2, Jianqin Feng3, Fangfang Liu1, Sihua Yang2, and Pengfei Zhang1
1 Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, [Qilu Hospital of Shandong University], Jinan 25001 2, China
2 MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, [South China Normal University], Guangzhou 510631, China
3 Department of Cardiology, [The Juye Hospital of Traditional Chinese Medicine], Heze 274900, China

Chin. Opt. Lett., 2018, 16(03): pp.031702

Topic:Medical optics and biotechnology
Keywords(OCIS Code): 170.5120  110.5120  

Photoacoustic imaging (PAI) has been used to characterize the spatial and quantitative features of lipid-rich atherosclerotic plaques with high sensitivity and specificity. In this Letter, we first validate that the ultra-low temperature and formaldehyde treatment have no effect on photoacoustic characteristics of the artery samples. Comparative experiments between the PAI and histological results demonstrate that the ultra-low temperature or formaldehyde treatment has few effects on the PAI of the lipid-rich atherosclerotic plaques; the lipid relative concentration and the lipid percentage by PAI hold high correlation with histology.

Copyright: © 2003-2012 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Posted online:2018/3/9

Get Citation: Mingjun Xu, Peng Lei, Jianqin Feng, Fangfang Liu, Sihua Yang, and Pengfei Zhang, "Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment," Chin. Opt. Lett. 16(03), 031702(2018)

Note: This work was supported by the National Natural Science Foundation of China (Nos. 61331001, 81571689, and 11774101), the Natural Science Foundation of Shandong Province (No. ZR2014HM084), the Science and Technology Planning Project of Guangdong Province, China (Nos. 2015B020233016, 2014B020215003, and 2014A020215031), the Distinguished Young Teacher Project in Higher Education of Guangdong, China (No. YQ2015049), and the Science and Technology Youth Talent for Special Program of Guangdong, China (No. 2015TQ01X882).


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