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Chin. Opt. Lett.
 Home  List of Issues    Issue 12 , Vol. 15 , 2017    10.3788/COL201715.120602


Real-time measurement of nano-particle size using differential optical phase detection
Qing Li1, He Huang1, Feng Lin2, and Xingkun Wu1
1 State Key Laboratory of Modern Optical Instrumentation, Department of Optical Engineering, [Zhejiang University], Hangzhou, Zhejiang 31 0027, China
2 School of Computer Engineering, [Nanyang Technological University], 637553, Singapore

Chin. Opt. Lett., 2017, 15(12): pp.120602

DOI:10.3788/COL201715.120602
Topic:Fiber optics and optical communication
Keywords(OCIS Code): 060.2370  290.5850  060.5060  

Abstract
We demonstrate a size sensing technique for nano-particles using optical differential phase measurement by a dual fiber interferometer through phase-generated carrier (PGC) demodulation. Nano-particle diameters are obtained from the differential phase shift as a result of adding an optical scattering perturbation into two-beam interference. Polystyrene nano-particles with diameters from 200 to 900 nm in a microfluidic channel are detected using this technique to acquire real-time particle diameters. Compared with amplitude sensing with over 10 mW of laser irradiance, particle sizing by PGC phase sensing can be achieved at a laser power as low as 1.18 mW. We further analyze major sources of noise in order to improve the limits of detection. This sensing technique may find a broad range of applications from the real-time selection of biological cell samples to rare cell detection in blood samples for early cancer screening.

Copyright: © 2003-2012 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Received:2017/9/12
Accepted:2017/10/20
Posted online:2017/11/6

Get Citation: Qing Li, He Huang, Feng Lin, and Xingkun Wu, "Real-time measurement of nano-particle size using differential optical phase detection," Chin. Opt. Lett. 15(12), 120602(2017)

Note: This work was supported in part by the National Natural Science Foundation of China (NSFC) under Grant No. 61378086.



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