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Chin. Opt. Lett.
 Home  List of Issues    Issue 08 , Vol. 15 , 2017    10.3788/COL201715.083001


Noninvasive blood glucose detection using a miniature wearable Raman spectroscopy system
Yi Zheng1;2, Xiangping Zhu1, Zhe Wang3, Zongyu Hou3, Fei Gao1, Rongzhi Nie1;4, Xiaoxia Cui1, Jiangbo She1, and Bo Peng1
1 State Key Laboratory of Transient Optics and Photonics, [Xi’an Institute of Optics and Precision Mechanics], Chinese Academy of Science (CAS), Xi’an 71 01 1 9, China
2 [University of Chinese Academy of Sciences (CAS)], Beijing 100049, China
3 State Key Laboratory of Power Systems, Department of Thermal Engineering, Tsinghua-BP Clean Energy Center,[ Tsinghua University], Beijing 100084, China
4 School of Science, [Xi’an Jiaotong University], Xi’an 71004 9, China

Chin. Opt. Lett., 2017, 15(08): pp.083001

DOI:10.3788/COL201715.083001
Topic:Spectroscopy
Keywords(OCIS Code): 300.6450  300.6190  120.4290  170.1470  

Abstract
In this Letter, a miniature wearable Raman spectroscopy system is developed. A wearable fiber-optic probe is employed to help the stable and convenient collection of Raman spectra. A nonlinear partial least squares model based on a multivariate dominant factor is employed to predict the glucose level. The mean coefficients of determination are 0.99, 0.893, and 0.844 for the glucose solution, laboratory rats, and human volunteers. The results demonstrate that a miniature wearable Raman spectroscopy system is feasible to achieve the noninvasive detection of human blood glucose and has important clinical application value in disease diagnosis.

Copyright: © 2003-2012 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Received:2017/2/22
Accepted:2017/5/18
Posted online:2017/6/16

Get Citation: Yi Zheng, Xiangping Zhu, Zhe Wang, Zongyu Hou, Fei Gao, Rongzhi Nie, Xiaoxia Cui, Jiangbo She, and Bo Peng, "Noninvasive blood glucose detection using a miniature wearable Raman spectroscopy system," Chin. Opt. Lett. 15(08), 083001(2017)

Note: This work was supported by the National Natural Science Foundation of China (NSFC) under Grant No. 61308086. We would like to thank the researchers from the Fourth Military Medical University for raising the rats and for the valuable suggestions.



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